TP47 vs TP15 vs TP17: Which antigens are best for Treponema Pallidum antibody detection?
TP47, TP15 and TP17 are three commonly used Treponema pallidum recombinant antigens in syphilis serological testing. This article compares their immunological roles, explains why multi-antigen combinations can broaden antibody recognition, and outlines how IVD manufacturers can select and validate antigen configurations for CLIA and ELISA assay development.